GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs867186 | 1 | rs6579211 | chr20:33605857 | TRPC4AP | chr20:33590215-33680618:- | 0.31 | 3.77 | 0.000182 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs6088813 | 1 | rs6579234 | chr20:33983485 | CEP250 | chr20:34042996-34099802:+ | -0.15 | -3.43 | 0.000658 | Height |
| THCA | cis | rs6088813 | 1 | rs6579234 | chr20:33983485 | CPNE1 | chr20:34213968-34262539:- | 0.31 | 5.96 | 4.83E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6579234 | chr20:33983485 | GDF5 | chr20:33897002-34042568:- | -0.18 | -3.81 | 0.000159 | Height |
| THCA | cis | rs6088813 | 1 | rs6579234 | chr20:33983485 | UQCC | chr20:33890383-33999833:- | 0.32 | 10.39 | 6.2E-23 | Height |
| THCA | cis | rs6579245 | 1 | rs6579245 | chr20:34125271 | CEP250 | chr20:34042996-34099802:+ | 0.21 | 3.52 | 0.000481 | Cholesterol, total |
| THCA | cis | rs6579245 | 1 | rs6579245 | chr20:34125271 | CPNE1 | chr20:34213968-34262539:- | -0.69 | -10.95 | 4.83E-25 | Cholesterol, total |
| THCA | cis | rs6579245 | 1 | rs6579245 | chr20:34125271 | UQCC | chr20:33890383-33999833:- | -0.2 | -4.52 | 7.71E-6 | Cholesterol, total |
| THCA | cis | rs7714584 | 1 | rs6579803 | chr5:150255559 | LOC134466 | chr5:150310000-150326146:- | 0.37 | 5.2 | 2.97E-7 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs6579803 | chr5:150255559 | ZNF300 | chr5:150273964-150284391:- | 0.15 | 3.4 | 0.000719 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs6579804 | chr5:150255931 | LOC134466 | chr5:150310000-150326146:- | 0.37 | 5.2 | 2.97E-7 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs6579804 | chr5:150255931 | ZNF300 | chr5:150273964-150284391:- | 0.15 | 3.4 | 0.000719 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs6579806 | chr5:150271084 | LOC134466 | chr5:150310000-150326146:- | 0.38 | 5.28 | 2.01E-7 | Crohn's disease |
| THCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | FAM119B | chr12:58166383-58176323:+ | 0.39 | 10.79 | 1.88E-24 | Multiple sclerosis |
| THCA | cis | rs703842 | 1 | rs6581155 | chr12:58178162 | METTL1 | chr12:58162352-58165914:- | -0.18 | -4.36 | 1.58E-5 | Multiple sclerosis |